definition : ( CD20 ) antibody mediated which is the function of B-cells , it is converted into plasma cells taht produce antibody IgA IgM IgG IgD IgE . IgA : surface antibody attack bacteria on the body surface like GI lumen respiratory lumen IgM : the largest and first one produced in responce to bacteria means acute infection . IgG : the smallest , only that cross the placenta , remains in serum as memory for old infection . IgE : responsible fpr allergy stimulate mast cells to release histamine . IgD : least important deficiency in humoral immunity increase risk of infection mainly bacteria ( encapsulated )
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